Genetic analysis of synaptic target recognition and assembly

Trends Neurosci. 2004 Sep;27(9):540-7. doi: 10.1016/j.tins.2004.07.003.


Formation of synapses by neurons onto specific targets is essential to the function of a nervous system. The isolation and analysis of Caenorhabditis elegans and Drosophila mutants with synaptogenesis defects has provided insight into the functions of evolutionarily conserved molecules at single-synapse resolution. Importantly, such studies have uncovered novel molecules and signaling mechanisms. Here, recent progress on synaptic target recognition and synaptic assembly are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans
  • Cell Communication / genetics*
  • Drosophila
  • Models, Neurological
  • Molecular Biology / methods
  • Neurons / cytology*
  • Neurons / physiology
  • Receptors, Cell Surface / physiology
  • Signal Transduction / genetics
  • Synapses / genetics*
  • Synaptic Transmission / genetics*
  • Ubiquitin / physiology


  • Receptors, Cell Surface
  • Ubiquitin