PER-1 production in a urinary isolate of Providencia rettgeri

J Chemother. 2004 Aug;16(4):343-6. doi: 10.1179/joc.2004.16.4.343.


A Providencia rettgeri strain resistant to extended-spectrum cephalosporins and intermediate to aztreonam was isolated from the urine of a patient hospitalized in the urology clinic of SSK Educational Hospital in Ankara. Clavulanic acid restored the activity of extended-spectrum cephalosporins, suggesting that the strain was harboring an extended-spectrum beta-lactamase. Since the PER-1 enzyme is widespread in Turkey, and had been already detected in a related species such as Proteus mirabilis, the Providencia strain was suspected of harboring a PER-1 enzyme, which was indeed detected by PCR. This is the first description in a P. rettgeri isolate of a PER-1 enzyme which is widespread among Acinetobacter baumanni and Pseudomonas aeruginosa strains in Turkey.

Publication types

  • Comparative Study

MeSH terms

  • Base Sequence
  • Cephalosporins / pharmacology*
  • DNA, Bacterial / analysis
  • Drug Resistance, Bacterial
  • Drug Resistance, Multiple, Bacterial*
  • Enterobacteriaceae Infections / diagnosis
  • Enterobacteriaceae Infections / drug therapy
  • Enterobacteriaceae Infections / epidemiology
  • Enterobacteriaceae Infections / urine
  • Humans
  • Incidence
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Providencia / classification
  • Providencia / drug effects*
  • Providencia / enzymology*
  • Turkey / epidemiology
  • Urinalysis
  • Urine / microbiology*
  • beta-Lactamases / metabolism*


  • Cephalosporins
  • DNA, Bacterial
  • beta-lactamase PER-1
  • beta-Lactamases