Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease

Proc Natl Acad Sci U S A. 1992 May 1;89(9):4187-91. doi: 10.1073/pnas.89.9.4187.

Abstract

Huntington disease is a neurological movement disorder involving massive neuronal death in the caudate-putamen region of the brain. Neither preventive nor curative therapy exists for this disease. The implantation of cross-species striatal neural precursor cells into the lesioned striatum of nonhuman primates (baboons) reduced the abnormal movements seen in the disease model. These abnormal movements reappeared after immunological rejection of the implanted striatal cells and were not modified by transplantation with nonstriatal cells. These findings encourage further experimentation toward the use of cell sources other than human fetal cells in a potential clinical application to Huntington disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apomorphine / pharmacology
  • Corpus Striatum / cytology
  • Corpus Striatum / transplantation*
  • Disease Models, Animal
  • Fetus
  • Huntington Disease / therapy*
  • Immunosuppression
  • Papio
  • Regression Analysis
  • Transplantation, Heterologous

Substances

  • Apomorphine