The efficacy of interferon-alpha in a patient with resistant familial Mediterranean fever complicated by polyarteritis nodosa

Intern Med. 2004 Jul;43(7):612-4. doi: 10.2169/internalmedicine.43.612.


Familial Mediterranean fever (FMF) is a recurrent self-limiting polyserositis. Polyarteritis nodosa (PAN) complicating FMF is very rare. Here, we present a 17-year-old male patient with FMF who subsequently developed PAN 2 weeks after hepatitis A infection. This case was also complicated with perirenal haematoma, and right nephrectomy was performed. The clinical condition of the patient was improved after therapy with intravenous and oral corticosteroid and intravenous cyclophosphamide. However, the FMF attacks and vasculitic skin lesions again occurred while he was using colchicine plus immunosuppressive agents a few months later. Interferon-alpha therapy was administered and the attacks were resolved within 3 months. He has not experienced any other symptom during the follow-up period of 28 months.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Angiography
  • Colchicine / therapeutic use
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Familial Mediterranean Fever / complications
  • Familial Mediterranean Fever / diagnosis
  • Familial Mediterranean Fever / drug therapy*
  • Follow-Up Studies
  • Humans
  • Interferon-alpha / administration & dosage*
  • Male
  • Polyarteritis Nodosa / complications
  • Polyarteritis Nodosa / diagnostic imaging
  • Polyarteritis Nodosa / drug therapy*
  • Risk Assessment
  • Severity of Illness Index
  • Tomography, X-Ray Computed
  • Treatment Outcome


  • Interferon-alpha
  • Colchicine