How MHC class II molecules work: peptide-dependent completion of protein folding

Immunol Today. 1992 Feb;13(2):43-6. doi: 10.1016/0167-5699(92)90131-P.


It is now clear that peptides play a key role in stabilizing the structure of MHC class II molecules. Here, Scheherazade Sadegh-Nasseri and Ron Germain propose that newly synthesized MHC class II, and indeed class I, molecules behave like partially folded proteins, with peptides acting as a surrogate portion of the MHC polypeptide structure that is necessary for completion of conformational maturation.

Publication types

  • Review

MeSH terms

  • Animals
  • Histocompatibility Antigens Class II / chemistry*
  • Hydrogen-Ion Concentration
  • Protein Conformation
  • Receptors, Antigen, T-Cell, alpha-beta / chemistry*
  • Structure-Activity Relationship


  • Histocompatibility Antigens Class II
  • Receptors, Antigen, T-Cell, alpha-beta