Induced high intraocular pressure, lasting more than one hour, is described in the rabbit. We inject simultaneously inside aqueous humor Epsilon Amino Caproic Acid 5 mg and Thrombin 20 U.S.N.I.H. units. To avoid leakage of aqueous humor we make the injection though a nou-perforating corneal preplaced loep and sight the suture to close the track when injection needle is taken out. We assume that high intraocular pressure is induced by 1% Adrenaline, 2% Pilocarpine and 1% Guanethidine solutions dropped in the eye each 5 mn, beginning 15 mn before anterior chamber injection and lasting during all the experiment. We point out this fact as a proof of the suitability of this method.