Rapid induction of glomerular lipidosis in APA hamsters by streptozotocin

Int J Exp Pathol. 1992 Feb;73(1):75-84.

Abstract

The pathology of male Syrian hamsters of APA strain which were injected intraperitoneally with 40 mg/kg body weight of streptozotocin (SZ) at 2 months of age was examined. It showed long-lasting prominent hyperglycaemia and hyperlipidaemia with glucosuria and the development of glomerular lipidosis from 1 month after SZ-injection (1 MAI). Glomerular lesions were restricted to the juxtamedullary cortex at 1 MAI and then extended to the subcapsular cortex. At 3 MAI, glomerular lesions were characterized by focal segmental glomerulosclerosis showing segmental expansion of the mesangial area due to an increase of basement membrane-like material and mesangial cells with lipid droplets and foam cells. SZ-induced diabetic APA hamsters will be a useful model for the investigation of glomerular lipidosis and focal segmental glomerulosclerosis.

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Cricetinae
  • Disease Models, Animal*
  • Glomerulosclerosis, Focal Segmental / chemically induced*
  • Hyperglycemia / chemically induced
  • Kidney Glomerulus / ultrastructure
  • Lipidoses / chemically induced*
  • Lipidoses / pathology
  • Male
  • Mesocricetus
  • Microscopy, Electron
  • Streptozocin / toxicity*
  • Time Factors

Substances

  • Streptozocin