Hematopoietin sub-family classification based on size, gene organization and sequence homology

Curr Biol. 1993 Sep 1;3(9):573-81. doi: 10.1016/0960-9822(93)90002-6.


The hematopoietins constitute a family of structurally related proteins that includes many cytokines, growth factors and hormones. We propose a classification for hematopoietins based on their size, gene organization and sequences; in addition, we further suggest that three cytokines, IL-11, IL-12 alpha chain and IL-13, are hematopoietins, and we place them in specific subgroups.