WRKY transcription factors: from DNA binding towards biological function

Curr Opin Plant Biol. 2004 Oct;7(5):491-8. doi: 10.1016/j.pbi.2004.07.012.


WRKY proteins comprise a large family of transcription factors. Despite their dramatic diversification in plants, WRKY genes seem to have originated in early eukaryotes. The cognate DNA-binding site of WRKY factors is well defined, but determining the roles of individual family members in regulating specific transcriptional programs during development or in response to environmental signals remains daunting. This review summarises the recent advances made in starting to unravel the various functions controlled by WRKY proteins.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • DNA-Binding Proteins / physiology
  • Models, Biological
  • Molecular Sequence Data
  • Multigene Family
  • Plant Proteins / genetics*
  • Plant Proteins / metabolism
  • Plant Proteins / physiology
  • Plants / genetics
  • Plants / metabolism*
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Transcription Factors / physiology


  • DNA-Binding Proteins
  • Plant Proteins
  • Transcription Factors