The intensity dependence of the auditory evoked N1 component as a predictor of response to Citalopram treatment in patients with major depression

Neurosci Lett. 2004 Sep 9;367(3):375-8. doi: 10.1016/j.neulet.2004.06.038.


The intensity dependence of the auditory evoked N1 ERP component (IDAP) has been suggested as an indicator of central serotonergic neurotransmission with relevance to pharmacological treatment. We report the results of a study evaluating the IDAP in 16 in-patients fulfilling DSM-IV criteria for major depressive episode in the course of treatment with the SSRI Citalopram. Our data revealed a significant correlation between the intensity slopes of the N1 amplitude prior to Citalopram treatment and treatment response: patients with higher intensity slopes of N1 amplitude showed a significantly stronger decrease of HDRS-Score after Citalopram treatment than patients within the lower intensity slope ranges. Our results indicate an association of N1 amplitude intensity dependence with response to antidepressant treatment with Citalopram.

Publication types

  • Comparative Study

MeSH terms

  • Acoustic Stimulation / methods
  • Adult
  • Antidepressive Agents, Second-Generation / pharmacology
  • Antidepressive Agents, Second-Generation / therapeutic use*
  • Citalopram / pharmacology
  • Citalopram / therapeutic use*
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / physiopathology
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • Electroencephalography / methods
  • Electrooculography / methods
  • Evoked Potentials, Auditory / drug effects*
  • Evoked Potentials, Auditory / radiation effects
  • Female
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Statistics as Topic


  • Antidepressive Agents, Second-Generation
  • Citalopram