Effect of lupeol isolated from Crataeva nurvala Buch.-Ham. stem bark extract against free radical induced nephrotoxicity in rats

Indian J Exp Biol. 2004 Jul;42(7):686-90.

Abstract

Lupeol, isolated from Crataeva nurvala stem bark in doses 40 and 80 mg/kg body weight, po, for 10 days, decreased the concentration of blood urea nitrogen, creatinine and lipid peroxidation and increased glutathione and catalase activities in cisplatin (5 mg/kg body weight, ip) induced nephrotoxicity in rats. The increased glutathione and catalase activities are indicative of antioxidant properties of lupeol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cisplatin / toxicity
  • Free Radicals
  • Kidney / drug effects*
  • Kidney / physiopathology
  • Male
  • Pentacyclic Triterpenes
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Free Radicals
  • Pentacyclic Triterpenes
  • Plant Extracts
  • Triterpenes
  • lupeol
  • Cisplatin