[Clinical study on treatment of patients with upper digestive tract malignant tumors of middle and late stage with Ginkgo biloba exocarp polysaccharides capsule preparation]

Zhong Xi Yi Jie He Xue Bao. 2003 Sep;1(3):189-91. doi: 10.3736/jcim20030313.
[Article in Chinese]


Objective: To observe the clinical efficacy of Ginkgo biloba exocarp polysaccharides (GBEP) capsule preparation in treating upper digestive tract malignant tumors of middle and late stage.

Methods: Eighty-six patients of the upper digestive tract malignant tumors were treated with GBEP capsule preparation taken orally. The clinical symptoms and the qualities of life of the patients with single GBEP and combined with operation, radiotherapy or intervention chemotherapy were observed. The tumor size was measured by electronic gastroscope before and after treatment with single GBEP. Objective response rate (RR) of the tumor was calculated. The survival period of patient was observed. The changes of blood routine examination in the patients treated with radiotherapy were observed.

Results: GBEP preparation could markedly improve the patients'clinical symptoms. Karnofsky scoring of the patients markedly increased after treatment. There were 2 CR (complete response, 6.3%), 22 PR (partial response, 68.8%)and 5 SD (stable disease, 15.6%) of 32 cases with single GBEP preparation. The survival periods of the 32 cases were markedly prolonged. The preparation could relieve the inhibited hematopietic function and the weight loss due to radiotherapy.

Conclusion: GBEP capsule preparation has some definite therapeutic effects on upper digestive tract malignant tumors of middle and late stage.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Capsules
  • Combined Modality Therapy
  • Esophageal Neoplasms / drug therapy*
  • Esophageal Neoplasms / mortality
  • Esophageal Neoplasms / radiotherapy
  • Female
  • Ginkgo biloba*
  • Humans
  • Male
  • Middle Aged
  • Phytotherapy
  • Plant Preparations / administration & dosage
  • Plant Preparations / therapeutic use*
  • Polysaccharides / administration & dosage
  • Polysaccharides / therapeutic use
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / radiotherapy
  • Survival Rate
  • Treatment Outcome
  • Upper Gastrointestinal Tract / drug effects
  • Upper Gastrointestinal Tract / pathology*
  • Upper Gastrointestinal Tract / radiation effects


  • Capsules
  • Plant Preparations
  • Polysaccharides