Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD

Neuron. 2004 Sep 2;43(5):596-9. doi: 10.1016/j.neuron.2004.08.025.

Abstract

Interactions between environmental and genetic factors may contribute to neurodegenerative disease. In this issue of Neuron, Calon et al. report that a diet low in an essential omega-3 polyunsaturated fatty acid (docosahexaenoic acid) depletes postsynaptic proteins and exacerbates behavioral alterations in a transgenic mouse model of Alzheimer's disease.

Publication types

  • Comment
  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / physiopathology
  • Animals
  • Brain / metabolism*
  • Brain / pathology
  • Brain / physiopathology
  • Disease Models, Animal
  • Docosahexaenoic Acids / metabolism*
  • Humans
  • Mice
  • Mice, Transgenic / genetics
  • Mice, Transgenic / metabolism
  • Nerve Tissue Proteins / metabolism*
  • Neuroprotective Agents / metabolism
  • Neuroprotective Agents / therapeutic use
  • Oxidative Stress / genetics

Substances

  • Nerve Tissue Proteins
  • Neuroprotective Agents
  • Docosahexaenoic Acids