NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

V Blank; P Kourilsky; A Israël

doi:10.1016/0968-0004(92)90321-y

NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

Trends Biochem Sci. 1992 Apr;17(4):135-40. doi: 10.1016/0968-0004(92)90321-y.

Authors

V Blank¹, P Kourilsky, A Israël

Affiliation

¹ Unité de Biologie Moléculaire du Gène, U. 277 INSERM, Institut Pasteur, Paris, France.

PMID: 1533967
DOI: 10.1016/0968-0004(92)90321-y

Abstract

Molecular cloning of the subunits of the transcription factor NF-kappa B and its inhibitor l kappa B revealed regions of sequence homology with two different classes of proteins: the Rel/dorsal family and a heterogeneous group of proteins containing ankyrin-like repeats. Both the Rel/dorsal homology domain and the ankyrin-like repeats appear to play important roles in protein-protein interactions that regulate localization and activity of the NF-kappa B subunits.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Animals
Ankyrins
Blood Proteins / chemistry
Gene Expression Regulation
Humans
Membrane Proteins / chemistry
Molecular Sequence Data
NF-kappa B / chemistry*
NF-kappa B / metabolism
Repetitive Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Transcription Factors / chemistry*
Transcription Factors / metabolism

Substances

Ankyrins
Blood Proteins
Membrane Proteins
NF-kappa B
Transcription Factors