NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

Trends Biochem Sci. 1992 Apr;17(4):135-40. doi: 10.1016/0968-0004(92)90321-y.


Molecular cloning of the subunits of the transcription factor NF-kappa B and its inhibitor l kappa B revealed regions of sequence homology with two different classes of proteins: the Rel/dorsal family and a heterogeneous group of proteins containing ankyrin-like repeats. Both the Rel/dorsal homology domain and the ankyrin-like repeats appear to play important roles in protein-protein interactions that regulate localization and activity of the NF-kappa B subunits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Ankyrins
  • Blood Proteins / chemistry
  • Gene Expression Regulation
  • Humans
  • Membrane Proteins / chemistry
  • Molecular Sequence Data
  • NF-kappa B / chemistry*
  • NF-kappa B / metabolism
  • Repetitive Sequences, Nucleic Acid
  • Sequence Homology, Nucleic Acid
  • Transcription Factors / chemistry*
  • Transcription Factors / metabolism


  • Ankyrins
  • Blood Proteins
  • Membrane Proteins
  • NF-kappa B
  • Transcription Factors