Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 3 (2), 109-16

Evaluation of Psychosocial Effects of Pre-Symptomatic Testing for Breast/Ovarian and Colon Cancer Pre-Disposing Genes: A 12-month Follow-Up

Affiliations

Evaluation of Psychosocial Effects of Pre-Symptomatic Testing for Breast/Ovarian and Colon Cancer Pre-Disposing Genes: A 12-month Follow-Up

Brita Arver et al. Fam Cancer.

Abstract

A prospective study of psychosocial consequences following predictive testing for inherited mutations in breast/ovarian and colon cancer susceptibility genes BRCA1, BRCA2, MLH1, and MSH2 was performed. Eighty-seven healthy women were tested for known family mutations and self-assessment scales were used to evaluate anxiety, depression and quality of life. Extensive pre- and post-test information was given. Questionnaires were responded before testing and four times after during the following year. A statistically significant decrease in anxiety mean scores over time was observed among the studied participants. The levels of depression in cancer genes carriers decreased over time while, surprisingly the levels in non-carriers increased. Compared to a normative Swedish sample all women tested showed similar levels of anxiety but women tested for breast cancer genes showed statistically lower levels of depression. Vitality dropped initially after disclosure of the testing of colon cancer genes carriers, followed by increasing levels. No change in vitality or in other quality of life parameters was seen in the other groups and the levels were similar to Swedish norm data. Most tested individuals were satisfied with the testing procedure including genetic counselling and testing and all of them but one would redo the testing. Healthy self-referred women going through predictive breast/ovarian or colon cancer gene testing, including extensive pre- and post-test information and support, in general, will not experience adverse psychological consequences.

Similar articles

See all similar articles

Cited by 16 articles

See all "Cited by" articles

References

    1. J Natl Cancer Inst. 1997 Jan 15;89(2):148-57 - PubMed
    1. J Clin Oncol. 2002 Jan 15;20(2):514-20 - PubMed
    1. Am J Med Genet. 2002 Aug 1;111(2):147-51 - PubMed
    1. Eur J Cancer. 1998 Nov;34(12):1922-6 - PubMed
    1. Int J Cancer. 2000 Jan 20;89(1):44-50 - PubMed

Publication types

MeSH terms

Feedback