From structure to disease: the evolving tale of aquaporin biology

Nat Rev Mol Cell Biol. 2004 Sep;5(9):687-98. doi: 10.1038/nrm1469.

Abstract

Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins - the aquaporins. These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis. The recognition of aquaporins has stimulated a reconsideration of membrane water permeability by investigators across a wide range of disciplines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Aquaporins* / chemistry
  • Aquaporins* / classification
  • Aquaporins* / genetics
  • Aquaporins* / metabolism
  • Astrocytes / cytology
  • Astrocytes / metabolism
  • Cell Membrane / metabolism
  • Eye / anatomy & histology
  • Eye / metabolism
  • Homeostasis
  • Humans
  • Kidney / anatomy & histology
  • Kidney / metabolism
  • Permeability
  • Phylogeny
  • Protein Conformation
  • Protein Isoforms / chemistry
  • Protein Isoforms / classification
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Respiratory System / anatomy & histology
  • Respiratory System / metabolism
  • Tissue Distribution
  • Water / metabolism*

Substances

  • Aquaporins
  • Protein Isoforms
  • Water