Cell Signalling and the Control of pre-mRNA Splicing

Nat Rev Mol Cell Biol. 2004 Sep;5(9):727-38. doi: 10.1038/nrm1467.


The transcripts of most metazoan protein-coding genes are alternatively spliced, but the mechanisms that are involved in the control of splicing are not well understood. Recent evidence supports the potential of both extra- and intracellular signalling to the splicing machinery as a means of regulating gene expression, and indicates that this form of gene control is widespread and mechanistically complex. However, important questions about these pathways need to be answered before this method of post-transcriptional regulation can be fully appreciated.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Brain / physiology
  • Cell Cycle / physiology
  • Gene Expression Regulation*
  • Hot Temperature
  • Humans
  • Hyaluronan Receptors / genetics
  • Hyaluronan Receptors / metabolism
  • Leukocyte Common Antigens / genetics
  • Leukocyte Common Antigens / metabolism
  • RNA Splicing*
  • Signal Transduction*
  • fas Receptor / metabolism


  • Hyaluronan Receptors
  • fas Receptor
  • Leukocyte Common Antigens