The SCF ubiquitin ligase: insights into a molecular machine

Nat Rev Mol Cell Biol. 2004 Sep;5(9):739-51. doi: 10.1038/nrm1471.


Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins - which are the substrate-recognition components of the Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase - are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cyclin-Dependent Kinases / metabolism
  • Drug Design
  • Evolution, Molecular
  • F-Box Proteins / classification
  • F-Box Proteins / genetics
  • F-Box Proteins / metabolism*
  • Humans
  • Models, Molecular
  • Protein Structure, Tertiary
  • SKP Cullin F-Box Protein Ligases / chemistry
  • SKP Cullin F-Box Protein Ligases / genetics
  • SKP Cullin F-Box Protein Ligases / metabolism*


  • F-Box Proteins
  • SKP Cullin F-Box Protein Ligases
  • Cyclin-Dependent Kinases