Metabolite profiling: from diagnostics to systems biology

Nat Rev Mol Cell Biol. 2004 Sep;5(9):763-9. doi: 10.1038/nrm1451.


The concept of metabolite profiling has been around for several decades, but only recent technical innovations have allowed metabolite profiling to be carried out on a large scale - with respect to both the number of metabolites measured and the number of experiments carried out. As a result, the power of metabolite profiling as a technology platform for diagnostics, and the research areas of gene-function analysis and systems biology, is now beginning to be fully realized.

Publication types

  • Review

MeSH terms

  • Cell Physiological Phenomena*
  • Magnetic Resonance Spectroscopy / methods
  • Mass Spectrometry / methods
  • Metabolism*
  • Molecular Diagnostic Techniques*
  • Proteins / chemistry
  • Proteins / metabolism
  • Proteomics / methods


  • Proteins