Cancer chromosomes in crisis

Nat Genet. 2004 Sep;36(9):932-4. doi: 10.1038/ng0904-932.


The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state.

Publication types

  • Comment
  • News

MeSH terms

  • Aneuploidy
  • Breast Neoplasms / genetics
  • Chromosomal Instability
  • Chromosome Aberrations*
  • Disease Progression
  • Female
  • Humans
  • Models, Biological
  • Neoplasms / genetics*
  • Telomere*