TIMP3 checks inflammation

Nat Genet. 2004 Sep;36(9):934-5. doi: 10.1038/ng0904-934.


Mice deficient in the metalloprotease inhibitor TIMP3, which inhibits the tumor-necrosis factor alpha (TNF-alpha)-converting enzyme (TACE, also called ADAM17), have elevated levels of TNF and severe inflammation in the liver. This result confirms the physiological importance of the soluble form of TNF and identifies TIMP3 as a crucial regulator of this inflammatory cytokine.

Publication types

  • News
  • Comment

MeSH terms

  • ADAM Proteins
  • ADAM17 Protein
  • Animals
  • Hepatitis, Chronic / genetics*
  • Inflammation / metabolism*
  • Liver Diseases / pathology
  • Metalloendopeptidases / antagonists & inhibitors
  • Mice
  • Mice, Mutant Strains
  • Tissue Inhibitor of Metalloproteinase-3 / physiology*
  • Tumor Necrosis Factor-alpha / metabolism


  • Tissue Inhibitor of Metalloproteinase-3
  • Tumor Necrosis Factor-alpha
  • ADAM Proteins
  • Metalloendopeptidases
  • ADAM17 Protein
  • Adam17 protein, mouse