From mRNA to tumor suppressor

Nat Genet. 2004 Sep;36(9):937-8. doi: 10.1038/ng0904-937.


The combination of inhibition of RNA degradation and comparative genomic scanning is a powerful new method for detecting gene disruptions. The utility of the method is well-illustrated by a series of observations linking the ephrin receptor EPHB2 to prostate cancer.

Publication types

  • Comment
  • News

MeSH terms

  • Emetine / pharmacology
  • Genes, Tumor Suppressor*
  • Humans
  • Male
  • Prostatic Neoplasms / genetics*
  • RNA Stability*
  • RNA, Messenger*
  • Receptor, EphB2 / genetics


  • RNA, Messenger
  • Receptor, EphB2
  • Emetine