Remission and regression of diabetic nephropathy

Curr Hypertens Rep. 2004 Oct;6(5):377-82. doi: 10.1007/s11906-004-0057-x.


Diabetic kidney disease is considered to be an irreversible and inexorable progressive disease. Therefore, prevention of development of ESRD is extremely important. Animal studies have demonstrated that regression of existing renal morphologic lesions is feasible. In a sizable fraction of type 1 diabetic patients with overt nephropathy, remission (decrease in albuminuria to <300 mg/24 h) was obtained (31%), and regression of diabetic nephropathy (rate of decline in GFR < or = 1 mL/min/y), achieved (22%) by aggressive antihypertensive treatment. Furthermore, remission of nephrotic-range albuminuria (from >2500 mg/24 h to <600 mg/24 h) have been demonstrated to be achievable in one fifth of patients with nephrotic-range albuminuria. Remission of nephrotic-range albuminuria was associated with a reduction in decline in GFR and improved survival free of ESRD. However, to prevent development of ESRD in diabetic patients, an aggressive multifactorial approach, aiming at lowering blood pressure and albuminuria, and improving glycemic control, must be applied.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Albuminuria
  • Animals
  • Antihypertensive Agents / therapeutic use*
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / diagnosis
  • Diabetes Mellitus, Type 1 / drug therapy
  • Diabetic Nephropathies / drug therapy*
  • Diabetic Nephropathies / prevention & control
  • Disease Progression
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Humans
  • Hypertension / complications
  • Hypertension / diagnosis
  • Hypertension / drug therapy
  • Kidney Failure, Chronic / drug therapy*
  • Kidney Failure, Chronic / prevention & control
  • Kidney Function Tests
  • Primary Prevention / methods*
  • Randomized Controlled Trials as Topic
  • Remission, Spontaneous
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome


  • Antihypertensive Agents