Functional analysis of human T cell subsets defined by CD45 isoform expression

Semin Immunol. 1992 Feb;4(1):35-41.


The properties of human CD45RA and CD45RO T cells are described. CD45RO cells respond to recall antigens and provide help for B lymphocytes. They produce a wide variety of cytokines including IL-2, IL-4 and IFN-gamma. CD45RA T cells respond poorly to recall antigens and produce mainly IL-2. The phenotype of CD45RO cells suggests that they may be in cycle and in vivo data shows that they have a short lifespan while CD45RA cells are long-lived. The lineage relationship of the two subsets is not clear but in vivo and in vitro evidence suggests bi-directional conversion between CD45RA and CD45RO phenotypes.

Publication types

  • Review

MeSH terms

  • Antigens, CD / analysis*
  • Antigens, CD / genetics
  • Antigens, CD / physiology
  • Cell Differentiation
  • Cell Movement
  • Cell Survival
  • Cytokines / metabolism
  • Gene Expression
  • Histocompatibility Antigens / analysis*
  • Histocompatibility Antigens / genetics
  • Histocompatibility Antigens / physiology
  • Humans
  • Immunologic Memory*
  • Leukocyte Common Antigens
  • Lymphocyte Activation
  • RNA Splicing
  • T-Lymphocyte Subsets / immunology*


  • Antigens, CD
  • Cytokines
  • Histocompatibility Antigens
  • Leukocyte Common Antigens