Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Sep;4(9):688-94.
doi: 10.1038/nrc1433.

Oncogenic Mechanisms of the Helicobacter Pylori CagA Protein


Oncogenic Mechanisms of the Helicobacter Pylori CagA Protein

Masanori Hatakeyama. Nat Rev Cancer. .


Infection with strains of Helicobacter pylori that carry the cytotoxin-associated antigen A (cagA) gene is associated with gastric carcinoma. Recent studies have shed light on the mechanism through which the cagA gene product, CagA, elicits pathophysiological actions. CagA is delivered into gastric epithelial cells by the bacterial type IV secretion system, where it deregulates the SHP2 oncoprotein. Intriguingly, CagA is noted for its variation, particularly at the SHP2-binding site, which could affect the potential of different strains of H. pylori to promote gastric carcinogenesis.

Similar articles

See all similar articles

Cited by 257 articles

See all "Cited by" articles

Publication types

MeSH terms


LinkOut - more resources