Stat3 is required for the development of skin cancer

J Clin Invest. 2004 Sep;114(5):619-22. doi: 10.1172/JCI22800.


Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that is constitutively activated in a variety of human malignancies, including prostate, lung, brain, breast, and squamous cell carcinomas. Inhibition of activated Stat3 leads to decreased proliferation and apoptosis of many cancer-derived cell lines, while the introduction of a constitutively activated form of Stat3 into immortalized human breast epithelial cells and rodent fibroblasts results in cellular transformation. Collectively, these data suggest a role for Stat3 in oncogenesis. A new study from Chan et al. is the first to demonstrate a requirement for Stat3 in de novo epithelial carcinogenesis in vivo. Using the two-step model of chemically induced skin carcinogenesis, the authors demonstrated that mice deficient in Stat3 were completely resistant to skin tumor development.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Mice
  • STAT3 Transcription Factor
  • Skin / metabolism*
  • Skin / pathology
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology
  • Trans-Activators / metabolism*


  • DNA-Binding Proteins
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Stat3 protein, mouse
  • Trans-Activators