Information theoretic similarity measures in non-rigid registration

Inf Process Med Imaging. 2003 Jul;18:378-87. doi: 10.1007/978-3-540-45087-0_32.


Mutual Information (MI) and Normalised Mutual Information (NMI) have enjoyed success as image similarity measures in medical image registration. More recently, they have been used for non-rigid registration, most often evaluated empirically as functions of changing registration parameter. In this paper we present expressions derived from intensity histogram representations of these measures, for their change in response to a local perturbation of a deformation field linking two images. These expressions give some insight into the operation of NMI in registration and are implemented as driving forces within a fluid registration framework. The performance of the measures is tested on publicly available simulated multi-spectral MR brain images.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Algorithms*
  • Brain / anatomy & histology*
  • Computer Simulation
  • Elasticity
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods
  • Information Theory
  • Magnetic Resonance Imaging / methods*
  • Models, Biological
  • Models, Statistical
  • Pattern Recognition, Automated*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*