CD23 expression in aged rats

Int Arch Allergy Immunol. 1992;97(4):330-6. doi: 10.1159/000236141.


CD23 is considered as an activation marker. Its expression on lymphocytes was studied during aging by using 1- to 142-week-old rats. Before analysis, all animals were injected with monoclonal IgE, in order to detect their full expression of CD23 molecules on their lymphocyte surface membranes. In elderly rats, a decrease was observed in the percentages of CD23+ lymphocytes from mesenteric lymph nodes, spleen, Peyer's patches and peripheral blood. In addition, these lymphocytes expressed significantly fewer CD23 molecules per cell. Almost all CD23+ cells belonged to the B lineage and were bearing both IgM and IgD on their membranes. It is suggested that a decrease in the number of both IgM+IgD+CD23+ lymphocytes and CD23 molecules per cell may contribute to immune deficiency in the elderly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology*
  • Analysis of Variance
  • Animals
  • Antigens, Differentiation, B-Lymphocyte / biosynthesis*
  • Female
  • Gene Expression
  • Immunoglobulin E / metabolism
  • Immunoglobulin M / analysis
  • Immunophenotyping
  • Lymphocytes / metabolism
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Fc / biosynthesis*
  • Receptors, IgE


  • Antigens, Differentiation, B-Lymphocyte
  • Immunoglobulin M
  • Receptors, Fc
  • Receptors, IgE
  • Immunoglobulin E