Regulation of protein kinases; controlling activity through activation segment conformation

Mol Cell. 2004 Sep 10;15(5):661-75. doi: 10.1016/j.molcel.2004.08.024.


There are currently at least forty-six unique protein kinase crystal structures, twenty-four of which are available in an active state. Here we examine these structures using a structural bioinformatics approach to understand how the conformation of the activation segment controls kinase activity.

Publication types

  • Review

MeSH terms

  • Amino Acid Motifs / physiology
  • Animals
  • Catalytic Domain / physiology
  • Computational Biology
  • Humans
  • Models, Molecular
  • Molecular Conformation*
  • Phosphorylation
  • Protein Kinases / chemistry*
  • Protein Structure, Tertiary / physiology
  • Sequence Homology, Amino Acid
  • Structure-Activity Relationship


  • Protein Kinases