Rate of recovery of D1 and D2 dopaminergic receptors in young vs. adult rat striatal tissue following alkylation with ethoxycarbonyl-ethoxy-dihydroquinoline (EEDQ)

Brain Res Dev Brain Res. 1992 Apr 24;66(2):286-9. doi: 10.1016/0165-3806(92)90095-e.


The rate of recovery of D1 and D2 receptor binding sites in rat striatal tissue labeled with [3H]SCH-23390 or [3H]YM-09151-2 was followed daily after irreversible blockade of these receptors with the alkylating agent ethoxycarbonyl-ethoxy-dihydroquinoline (EEDQ). These rates were significantly higher in young post-weaning rats than in young adults (14% vs. 7% per day). The findings suggest that rates of synthesis of new D1 and D2 receptor proteins may be increased during a phase of neurodevelopment in the first postnatal month when the accumulation of both receptor types, especially of D1 receptors, is about maximal.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkylating Agents / pharmacology*
  • Animals
  • Corpus Striatum / drug effects*
  • Corpus Striatum / growth & development
  • Male
  • Quinolines / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / drug effects*
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2


  • Alkylating Agents
  • Quinolines
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • EEDQ