Chronic toxicity of Gynostemma pentaphyllum

Fitoterapia. 2004 Sep;75(6):539-51. doi: 10.1016/j.fitote.2004.04.010.


The effect of water extract of Gynostemma pentaphyllum was evaluated on 6-month chronic toxicity in Wistar rats. Control group received orally 10 ml kg(-1) day(-1). The extract was orally given to the five treatment groups at the doses of 6, 30, 150, 750 and 750 mg kg(-1) day(-1) for 24 weeks. The last group served as the recovery group. The results showed that the extract did not produce any significant dose-related changes. Therefore, it is concluded that the extract of G. pentaphyllum at the given doses did not produce any significant toxic effect in rats during 6-month period of the treatment.

MeSH terms

  • Administration, Oral
  • Animals
  • Blood Chemical Analysis
  • Body Weight
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Gynostemma*
  • Male
  • Organ Size
  • Phytotherapy*
  • Plant Components, Aerial
  • Plant Extracts / administration & dosage
  • Plant Extracts / toxicity*
  • Rats
  • Rats, Wistar


  • Plant Extracts