Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare

Fitoterapia. 2004 Sep;75(6):557-65. doi: 10.1016/j.fitote.2004.05.005.

Abstract

Oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions and showed a central analgesic effect. Moreover, it significantly increased the plasma superoxide dismutase (SOD) and catalase activities and the high density lipoprotein-cholesterol level. On the contrary, the malondialdehyde (MDA) (as a measure of lipid peroxidation) level was significantly decreased in F. vulgare fruit methanolic extract group compared to the control group (P<0.05). These results seems to support the use of F. vulgare fruit methanolic extract in relieving inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Analgesics / administration & dosage
  • Analgesics / pharmacology
  • Analgesics / therapeutic use
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Arachidonic Acid
  • Carrageenan
  • Catalase / blood
  • Cholesterol, HDL / blood
  • Edema / chemically induced
  • Edema / prevention & control*
  • Foeniculum*
  • Fruit
  • Hot Temperature
  • Lipid Peroxidation / drug effects
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred ICR
  • Pain / chemically induced
  • Pain / prevention & control*
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Sprague-Dawley
  • Superoxide Dismutase / blood

Substances

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Cholesterol, HDL
  • Plant Extracts
  • Arachidonic Acid
  • Carrageenan
  • Catalase
  • Superoxide Dismutase