Effects of mechanical load on flow, volume and pressure delivered by high-frequency percussive ventilation

Respir Physiol Neurobiol. 2004 Aug 20;142(1):81-91. doi: 10.1016/j.resp.2004.04.005.


High-frequency percussive ventilation (HFPV) has proved its unique efficacy in the treatment of acute respiratory distress, when conventional mechanical ventilation (CMV) has demonstrated a limited response. We analysed flow (V(dot)), volume (V) and airway pressure (Paw) during ventilation of a single-compartment mechanical lung simulator, in which resistance (R) and elastance (E) values were modified, while maintaining the selected ventilatory settings of the HFPV device. These signals reveal the physical effect of the imposed loads on the output of the ventilatory device, secondary to constant (millisecond by millisecond) alterations in pulmonary dynamics. V(dot), V and Paw values depended fundamentally on the value of R, but their shapes were modified by R and E. Although peak Paw increased 70.3% in relation to control value, mean Paw augmented solely 36.5% under the same circumstances (maximum of 9.4 cm H2O). Finally, a mechanism for washing gas out of the lung was suggested.

Publication types

  • Comparative Study

MeSH terms

  • Airway Resistance / physiology*
  • High-Frequency Ventilation / methods*
  • Humans
  • Lung / physiology*
  • Lung Volume Measurements
  • Pulmonary Ventilation / physiology*
  • Respiration*
  • Respiration, Artificial
  • Tidal Volume / physiology*