Soluble interleukin-2 receptor in cancer

Front Biosci. 2004 Sep 1:9:3085-90. doi: 10.2741/1461.


Levels of serum sIL-2R (soluble interleukin-2 receptor) reflect the total amount of activated T lymphocytes in tumor infiltrating lymphocytes of cancer tissues and metastatic organs, because a part of alpha-chain of IL-2R is released into the bloodstream on the attachment of IL-2 (interleukin-2) to its specific IL-2R membrane. In most malignant diseases, elevated levels of serum sIL-2R are found, compare to normal control. Serum sIL-2R is a useful parameter for evaluating the disease stage and monitoring the disease progression during the post-treatment follow-up, though it is not an organ-specific parameter.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor*
  • Disease Progression
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Interleukin-2 / metabolism
  • Lymphocytes, Tumor-Infiltrating / metabolism
  • Male
  • Neoplasms / metabolism*
  • Receptors, Interleukin-2 / blood*
  • Receptors, Interleukin-2 / physiology*


  • Biomarkers, Tumor
  • Interleukin-2
  • Receptors, Interleukin-2