Abstract
Carbon monoxide (CO) has long been known to have dramatic physiological effects on organisms ranging from bacteria to humans, but recently there have a number of suggestions that organisms might have specific sensors for CO. This article reviews the current evidence for a variety of proteins with demonstrated or potential CO-sensing ability. Particular emphasis is placed on the molecular description of CooA, a heme-containing CO sensor from Rhodospirillum rubrum, since its biological role as a CO sensor is clear and we have substantial insight into the basis of its sensing ability.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Bacteria / metabolism
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Carbon Monoxide / analysis
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Carbon Monoxide / metabolism*
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Eukaryotic Cells / physiology
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Gene Expression Regulation*
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Hemeproteins / chemistry
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Hemeproteins / genetics
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Hemeproteins / metabolism*
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Humans
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Models, Molecular
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Molecular Sequence Data
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Signal Transduction*
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Trans-Activators / chemistry
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Trans-Activators / genetics
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Trans-Activators / metabolism*
Substances
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Bacterial Proteins
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CooA protein, Rhodospirillum rubrum
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Hemeproteins
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Trans-Activators
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Carbon Monoxide