Aspirin use in advanced uncontrolled glaucoma

J Glaucoma. 2004 Oct;13(5):365-70. doi: 10.1097/01.ijg.0000133148.59933.50.


Purpose: To evaluate if aspirin use affects progression of primary open angle glaucoma (POAG).

Methods: A retrospective review of patients with uncontrolled glaucoma was performed. Incidence of aspirin use was noted by a one-time self-reporting survey. Controls were medically stable patients diagnosed with POAG. The primary outcome measure studied was a comparison of percentages of aspirin use in patients who have and have not undergone glaucoma filtering surgery (trabeculectomy).

Results: Forty-one percent (26/64) of the patients in the trabeculectomy group and 23% (17/74) of controls were using aspirin. Patients undergoing trabeculectomy were twice as likely to take aspirin (O.R., 2.29; 95% C.I., 1.10-4.79). Subgroup analyses demonstrated increased aspirin use in those operative patients who are current or former smokers (O.R., 3.71; 95% C.I., 1.10-12.56), have systemic hypertension (O.R., 3.30; 95% C.I., 1.02-22.58), or have joint disease (O.R., 4.60; 95% C.I., 1.34-15.82).

Conclusion: A higher concurrence of aspirin use was observed in patients with POAG who required surgical management compared with patients having relatively medically stable glaucoma. This may be secondary to a higher rate of glaucoma surgery performed on patients with greater systemic illnesses, more of whom use aspirin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aspirin / therapeutic use*
  • Cardiovascular Diseases / complications
  • Cohort Studies
  • Disease Progression
  • Female
  • Glaucoma, Open-Angle / complications
  • Glaucoma, Open-Angle / physiopathology*
  • Glaucoma, Open-Angle / surgery
  • Humans
  • Joint Diseases / complications
  • Male
  • Retrospective Studies
  • Trabeculectomy
  • Visual Fields


  • Aspirin