Dietary phylloquinone intake as a potential marker for a heart-healthy dietary pattern in the Framingham Offspring cohort

J Am Diet Assoc. 2004 Sep;104(9):1410-4. doi: 10.1016/j.jada.2004.06.021.


Abstract Associations were evaluated among self-reported dietary intakes of phylloquinone (vitamin K-1), lifestyle characteristics, and intermediary markers of cardiovascular disease risk in a population-based cohort of men and women. Dietary phylloquinone intakes were assessed by food frequency questionnaire in 1,338 men and 1,603 women (mean age, 54 years) participating in the Framingham Heart Study. Cross-sectional associations with lifestyle characteristics and lipid profiles, including total cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol, and triglyceride concentrations, were estimated across increasing quintile categories of phylloquinone intakes. Participants in the highest quintile category of phylloquinone intake consumed more fruit, vegetables, fish, dietary fiber, and dietary supplements ( P <.001), and consumed less meat and less saturated fat ( P <.001). Higher phylloquinone intakes were also associated with lower triglyceride concentrations ( P <.001). In conclusion, a high phylloquinone intake may be a marker for an overall heart-healthy dietary pattern.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antifibrinolytic Agents / administration & dosage*
  • Antifibrinolytic Agents / blood
  • Biomarkers / blood
  • Cholesterol / blood
  • Cohort Studies
  • Cross-Sectional Studies
  • Diet*
  • Dietary Fats / administration & dosage
  • Female
  • Heart Diseases / blood*
  • Heart Diseases / epidemiology
  • Heart Diseases / etiology
  • Humans
  • Life Style
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Risk Factors
  • Smoking
  • Surveys and Questionnaires
  • Triglycerides / blood*
  • Vitamin K 1 / administration & dosage*
  • Vitamin K 1 / blood


  • Antifibrinolytic Agents
  • Biomarkers
  • Dietary Fats
  • Triglycerides
  • Vitamin K 1
  • Cholesterol