Will the new cytogenetics replace the old cytogenetics?

Clin Genet. 2004 Oct;66(4):265-75. doi: 10.1111/j.1399-0004.2004.00316.x.


With the advent of array-based comparative genomic hybridization technology, the analog cytogenetic analysis that has been used for the past 100 years could be replaced by the quantitative, microarray-based molecular analysis. Major advantages of the new array-based cytogenetic technologies are the high resolution and the high throughput. This technology is the first to offer an autonomous whole-chromosome analysis in one hybridization reaction for the detection of submicroscopic gains/losses. However, as with any new technology, it needs to be validated with regard to its performance in various applications (e.g. clinical genetic testing and cancer applications), comparative cost, and the data interpretation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Chromosome Aberrations*
  • Cytogenetics / methods*
  • Humans
  • Nucleic Acid Hybridization*