[Effects of angiotensin-(1-7) on remodeling of myocardial collagen network in pressure-overloaded rats]

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Sep;16(9):523-6.
[Article in Chinese]

Abstract

Objective: To investigate the effects of angiotensin-(1-7) on remodeling of myocardial collagen network in pressure-overloaded rats.

Methods: A rat model of pressure-overloaded heart was induced by constriction of abdominal aorta. Seventy-five male Sprague Dawley rats were randomized to sham-operated group, model control group and angiotensin-(1-7) group. The rats of the latter two groups were treated with intravenous infusion of either angiotensin-(1-7) (25 microg x kg(-1) x h(-1)) or saline after operation. Ratio of left ventricular weight to body weight (LVW/BW) and myocardial collagen volume fraction (CVF) were determined at 1 and 4 weeks after operation. And types I and III collagen mRNA expressions were assessed with reverse transcription-polymerase chain reaction (RT-PCR).

Results: At 1 week after the operation, types I and III collagen mRNA expressions of the left ventricular myocardium in model group and angiotensin-(1-7) group were increased significantly compared with those in sham-operated group. But those in angiotensin-(1-7) group were significantly lower than that in model group. At 4 weeks after the operation, LVW/BW and CVF were increased significantly in model group and angiotension-(1-7) group compared with those in sham-operated group, but those in angiotension-(1-7) group were significantly lower than that of model group.

Conclusion: Angiotensin -(1-7) can attenuate remodeling of myocardial collagen network in pressure-overloaded rats.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensins / pharmacology*
  • Animals
  • Collagen / metabolism*
  • Male
  • Myocardium / metabolism*
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Ventricular Remodeling / drug effects*

Substances

  • Angiotensins
  • RNA, Messenger
  • Collagen