Intraepithelial lymphocytes in celiac disease: license to kill revealed

Immunity. 2004 Sep;21(3):303-4. doi: 10.1016/j.immuni.2004.08.002.


Infiltration of lymphocytes in the small intestinal epithelium is a hallmark of active celiac disease. In this issue of Immunity, two papers uncover mechanisms controlling the cytolytic potential of these cells and provide evidence that lymphocyte killing of enterocytes is an important part of the celiac disease pathogenesis.

Publication types

  • Comment

MeSH terms

  • Celiac Disease / immunology*
  • Celiac Disease / pathology
  • Enterocytes / immunology
  • Enterocytes / pathology
  • Humans
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / pathology
  • Intestine, Small / immunology*
  • Intestine, Small / pathology
  • T-Lymphocytes / immunology*