Anti-HIV activity of some synthetic lignanolides and intermediates

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4483-6. doi: 10.1016/j.bmcl.2004.06.047.


The evaluation of the anti-HIV-1 activity of synthetic lignanolides and their intermediates is reported. The antiviral activity was studied through luciferase-based assays targeting the HIV-1 promoter activation induced by either, the HIV-1 Tat protein or the cellular transcription factor NF-kappaB, both known as crucial factors in HIV-1 replication. Among the compounds tested, three of them 2, 4 and 13 were further analysed for their anti-HIV-1 activity by recombinant virus assays, showing a suitable profile for development of novel anti-HIV-1 drugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / metabolism
  • Anti-HIV Agents / pharmacology
  • HIV-1 / drug effects*
  • HIV-1 / physiology
  • HeLa Cells
  • Humans
  • Lignans / chemistry*
  • Lignans / metabolism
  • Lignans / pharmacology


  • Anti-HIV Agents
  • Lignans