Reversible cerebellar lesions induced by metronidazole therapy for helicobacter pylori

J Neuroimaging. 2004 Oct;14(4):369-71. doi: 10.1177/1051228404267597.

Abstract

Metronidazole is widely used for chronic or refractory infection and has recently also been used for the treatment of Helicobacter pylori. The authors report the case of a Japanese patient presenting with reversible cerebellar lesions induced by prolonged administration of metronidazole for treatment of H pylori with magnetic resonance imaging findings. Although rare, prolonged and high-dose administration of metronidazole may induce cerebellar lesions. Increased awareness of this phenomenon is important, as these lesions are reversible with discontinuation of this drug.

Publication types

  • Case Reports

MeSH terms

  • Anti-Infective Agents / adverse effects*
  • Anti-Infective Agents / therapeutic use
  • Cerebellar Diseases / chemically induced*
  • Female
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Magnetic Resonance Imaging
  • Metronidazole / adverse effects*
  • Metronidazole / therapeutic use
  • Middle Aged

Substances

  • Anti-Infective Agents
  • Metronidazole