Alcohol intake and osseointegration around implants: a histometric and scanning electron microscopy study

Implant Dent. 2004 Sep;13(3):238-44. doi: 10.1097/


Alveolar wound healing can be modified by local and systemic factors. The aim of this study was to evaluate the possible effect of alcoholic beverage administration (sugarcane brandy) on reparative bone formation around hydroxyapatite/tricalcium phosphate implants inside the alveolar socket. Male Wistar rats had their upper right incisors extracted and the bioceramic granules implanted in the alveoli. The animals received increasing concentrations of brandy until 30 degrees Gay-Lussac was achieved starting 30 days before dental extraction and maintained for periods varying from 1 hour to 6 weeks, until sacrifice. Blood alcohol concentration analysis was performed as well as histological and histometric analysis through light and scanning electron microscopy to examine the relation between alveolar healing components, including new bone trabeculae, and the implants. Blood alcohol concentration was significantly higher in treated animals compared with controls. A significant delay in reparative bone formation was detected in the alveolus of alcoholic rats by a histometric differential point counting method, whereas the presence of the bioceramic in the alveolar socket improved alveolar wound healing in alcohol-treated rats. It is suggested that the osteoconductive properties of this bioceramic accelerated alveolar wound healing in alcoholic rats.

MeSH terms

  • Alcohol Drinking / adverse effects*
  • Animals
  • Calcium Phosphates
  • Dental Implantation, Endosseous
  • Dental Implants
  • Durapatite
  • Ethanol / adverse effects
  • Implants, Experimental
  • Male
  • Microscopy, Electron, Scanning
  • Osseointegration / drug effects*
  • Rats
  • Rats, Wistar
  • Statistics, Nonparametric
  • Tooth Socket


  • Calcium Phosphates
  • Dental Implants
  • Ethanol
  • Durapatite
  • tricalcium phosphate