This article aims to provide an overview of the disease prevention and health promotion work carried out by CLSC nurses working with infants, children and youth. A second objective is to present our synthesis of four recent studies on the state of prevention-promotion in these organizations. This is followed by our analysis of several contemporary issues related to nursing practice in this intervention sector. While disease prevention and health promotion is a major component of the practice of CLSC nurses who work with infants, children and youth, it is an intervention sector that has been weakened by numerous changes affecting these organizations in the wake of the reform. The discussion thus proposes several courses of research and action in the hopes of strengthening this major component of the CLSC mission.