E2F target genes: unraveling the biology

Trends Biochem Sci. 2004 Aug;29(8):409-17. doi: 10.1016/j.tibs.2004.06.006.


The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development. These new findings greatly enrich our understanding of how E2F controls transcription and cellular homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / physiology*
  • Cell Differentiation*
  • DNA Damage
  • DNA Repair / physiology*
  • DNA Replication / physiology*
  • DNA-Binding Proteins / physiology*
  • E2F Transcription Factors
  • Forecasting
  • Humans
  • Mitosis / physiology*
  • Transcription Factors / physiology*


  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Transcription Factors