Blood levels and acute response to bupropion

Am J Psychiatry. 1992 Mar;149(3):399-400. doi: 10.1176/ajp.149.3.399.


Twenty-three patients with major depressive disorder were treated with bupropion in an open-design protocol. Fifteen (65.2%) of the 23 responded with a more than 50% decrease in scores on the Beck Depression Inventory. Patients with trough blood levels of 10-29 ng/ml had a significantly better response than those with trough levels of 30 ng/ml or more. This preliminary result warrants further, double-blind evaluation.

MeSH terms

  • Adult
  • Bupropion / blood*
  • Bupropion / therapeutic use
  • Female
  • Humans
  • Male
  • Middle Aged


  • Bupropion