Steering growth cones with a CaMKII/calcineurin switch

Fan Wang

doi:10.1016/j.neuron.2004.09.002

Steering growth cones with a CaMKII/calcineurin switch

Neuron. 2004 Sep 16;43(6):760-2. doi: 10.1016/j.neuron.2004.09.002.

Author

Fan Wang¹

Affiliation

¹ Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC 27710, USA.

PMID: 15363387
DOI: 10.1016/j.neuron.2004.09.002

Abstract

Calcium can regulate and induce both attractive and repulsive turnings by growth cones. In this issue of Neuron, Wen et al. report that differential activations of CaMKII and calcineurin (CaN) act as the read out for distinct patterns of intracellular calcium signals and a switch between attraction and repulsion.

Publication types

Comment
Comparative Study

MeSH terms

Animals
Calcineurin / physiology*
Calcium / metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases / physiology*
Growth Cones / physiology*
Signal Transduction / physiology
Xenopus

Substances

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Calcineurin
Calcium