Genetic progression of metastatic melanoma

Cancer Lett. 2004 Oct 28;214(2):133-47. doi: 10.1016/j.canlet.2004.06.049.


Melanoma progression is well defined in its clinical, histopathological and biological aspects, but the molecular mechanism involved and the genetic markers associated to metastatic dissemination are only beginning to be defined. The recent development of high-throughput technologies aimed at global molecular profiling of cancer is switching on the spotlight at previously unknown candidate genes involved in melanoma, such as WNT5A and BRAF. In fact, several tumor suppressors and oncogenes have been shown to be involved in melanoma pathogenesis, including CDKN2A, PTEN, TP53, RAS and MYC, though they have not been related to melanoma subtypes or validated as prognostic markers. Here, we have reviewed the published data relative to the major genes involved in melanoma pathogenesis, which may represent important markers for the identification of genetic profiles of melanoma subtypes.

Publication types

  • Review

MeSH terms

  • Disease Progression
  • Genetic Markers*
  • Genetic Predisposition to Disease
  • Humans
  • Melanoma / genetics*
  • Melanoma / physiopathology*
  • Neoplasm Metastasis / genetics*
  • Prognosis
  • Signal Transduction
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / physiopathology*


  • Genetic Markers