Biology and pathology of nectins and nectin-like molecules

Toshiaki Sakisaka; Yoshimi Takai

doi:10.1016/j.ceb.2004.07.007

Biology and pathology of nectins and nectin-like molecules

Curr Opin Cell Biol. 2004 Oct;16(5):513-21. doi: 10.1016/j.ceb.2004.07.007.

Authors

Toshiaki Sakisaka¹, Yoshimi Takai

Affiliation

¹ Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Osaka 565-0871, Japan.

PMID: 15363801
DOI: 10.1016/j.ceb.2004.07.007

Abstract

Immunoglobulin-like nectins contribute to the formation of a variety of cell-cell junctions, acting cooperatively with, or independently of, cadherins. In addition, nectins heterophilically trans-interact with nectin-like molecules (Necls), which are involved in cell adhesion, migration, and proliferation, and assist or modify their functions. On the other hand, nectins and Necls serve as viral receptors and are associated with human diseases (including cancer) when mutated or upregulated.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Adhesion Molecules / physiology*
Cell Proliferation
Intercellular Junctions / physiology*
Models, Biological
Receptors, Virus / physiology*
Signal Transduction / physiology*

Substances

Cell Adhesion Molecules
Receptors, Virus