Integrin-linked kinase: integrin's mysterious partner

Curr Opin Cell Biol. 2004 Oct;16(5):565-71. doi: 10.1016/j.ceb.2004.07.004.

Abstract

Integrin-mediated cell adhesion regulates a vast number of biological processes including migration, survival and proliferation of cells. It is therefore not surprising that defects in integrin function are often rate-limiting for development and profoundly affect the progression of several diseases. The functions of integrins are mediated through the recruitment of cytoplasmic plaque proteins. One of these is integrin-linked kinase, which connects integrins to the actin cytoskeleton and transduces signals through integrins to the extracellular matrix and from integrins to various subcellular compartments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actinin / metabolism
  • Actins / metabolism
  • Adaptor Proteins, Signal Transducing
  • Animals
  • Binding Sites
  • Cell Adhesion / physiology
  • Cytoplasm / physiology*
  • Cytoskeleton / metabolism*
  • DNA-Binding Proteins / metabolism
  • Extracellular Matrix / metabolism
  • Integrins / metabolism
  • Integrins / physiology*
  • LIM Domain Proteins
  • Membrane Proteins
  • Microfilament Proteins
  • Models, Biological
  • Protein Binding
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Serine-Threonine Kinases / physiology*
  • Signal Transduction / physiology*

Substances

  • Actins
  • Adaptor Proteins, Signal Transducing
  • DNA-Binding Proteins
  • Integrins
  • LIM Domain Proteins
  • Lims1 protein, mouse
  • Membrane Proteins
  • Microfilament Proteins
  • PARVA protein, human
  • PARVB protein, human
  • Actinin
  • integrin-linked kinase
  • Protein-Serine-Threonine Kinases