Abstract
Integrin-mediated cell adhesion regulates a vast number of biological processes including migration, survival and proliferation of cells. It is therefore not surprising that defects in integrin function are often rate-limiting for development and profoundly affect the progression of several diseases. The functions of integrins are mediated through the recruitment of cytoplasmic plaque proteins. One of these is integrin-linked kinase, which connects integrins to the actin cytoskeleton and transduces signals through integrins to the extracellular matrix and from integrins to various subcellular compartments.
Copyright 2004 Elsevier Ltd.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Actinin / metabolism
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Actins / metabolism
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Adaptor Proteins, Signal Transducing
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Animals
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Binding Sites
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Cell Adhesion / physiology
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Cytoplasm / physiology*
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Cytoskeleton / metabolism*
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DNA-Binding Proteins / metabolism
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Extracellular Matrix / metabolism
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Integrins / metabolism
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Integrins / physiology*
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LIM Domain Proteins
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Membrane Proteins
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Microfilament Proteins
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Models, Biological
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Protein Binding
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Protein-Serine-Threonine Kinases / metabolism
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Protein-Serine-Threonine Kinases / physiology*
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Signal Transduction / physiology*
Substances
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Actins
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Adaptor Proteins, Signal Transducing
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DNA-Binding Proteins
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Integrins
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LIM Domain Proteins
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Lims1 protein, mouse
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Membrane Proteins
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Microfilament Proteins
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PARVA protein, human
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PARVB protein, human
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Actinin
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integrin-linked kinase
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Protein-Serine-Threonine Kinases